E-Pharm TestForce 2 D-Aspartic Acid
NEW Formula TestForce 2 now with Sarcosine - Chelated D-Aspartate - Natural TestElevator. TestForce 2 contains the most soluble form of d-aspartic acid combined with another remarkable amino acid known as sarcosine. This combination provides results clearly superior to other d-aspartic acid product formulations.
In case you aren’t aware, d-aspartic acid is the hottest supplement ingredient on the market right now. It has more scientific literature supporting its ability to act as a natural regulator of Test release in the body than any supplement ingredient EVER.
E-Pharm was the company to bring you the premium form of d-aspartic acid – d-aspartate calcium chelate. This form is more than 75 times as water soluble as regular d-aspartic acid and soluble over a wide pH range. This ensures the most rapid and complete absorption possible. And now E-Pharm has taken the lead in d-aspartic acid technology again with the patent pending addition of the amino acid sarcosine.
Please allow me to explain why the inclusion of sarcosine is so vital to getting the most out of d-aspartic acid.
In case you aren’t aware, d-aspartic acid is the hottest supplement ingredient on the market right now. It has more scientific literature supporting its ability to act as a natural regulator of Test release in the body than any supplement ingredient EVER.
E-Pharm was the company to bring you the premium form of d-aspartic acid – d-aspartate calcium chelate. This form is more than 75 times as water soluble as regular d-aspartic acid and soluble over a wide pH range. This ensures the most rapid and complete absorption possible. And now E-Pharm has taken the lead in d-aspartic acid technology again with the patent pending addition of the amino acid sarcosine.
Please allow me to explain why the inclusion of sarcosine is so vital to getting the most out of d-aspartic acid.
Why Sarcosine?
Let me start with some background. When d-aspartic acid (DAA) is ingested it is absorbed into the body and taken up preferentially by endocrine tissues such as the hypothalamus, pituitary, and testicles. There it stimulates the activity of what are known as NMDA receptors. NMDA receptors are located on neurons and they regulate neuronal activity. DAA binds to a specific docking site (receptor) located on the NMDA receptor known as NMDA binding site.
In the hypothalamus the stimulation of NMDA receptors leads to the production of gonadotropin releasing hormone (GnRH). GnRH then stimulates the pituitary gland to release luteinizing hormone (LH) and follicle stimulating hormone (FSH). LH and FSH then in turn travel to the testicles to initiate the process of steroidogenesis, which leads eventually to the release of test into the blood stream. Stimulation of NMDA receptors in the hypothalamus also leads to the release of growth hormone releasing hormone (GHRH) which in turn promotes the release of growth hormone from the pituitary gland.
So the key here is the NMDA receptor. The more you activate this receptor in the hypothalamus the greater the release of GnRH and GHRH, and ultimately Test and G H.
The NMDA receptor is somewhat unique in that it requires activation by two ligands (a ligand is like a “key” to a receptor). In the hypothalamus the main ligand for the NMDA receptor is d-aspartic acid. The secondary ligand (or co-activator) is the amino acid glycine. Both DAA and glycine have specific binding sites on the NMDA receptor. These sites are known as the NMDA binding site and the glycine binding site respectively. Think of it this way - just like how firing a nuclear missile requires two soldiers to turn two separate keys, so the NMDA receptor requires binding by two ligands to initiate its influence on the firing of a neuronal signal.
So to review, administration of DAA leads to it’s uptake into the hypothalamus and binding to the NMDA receptors there. And to activate the NMDA receptor you also require adequate levels of ligands that bind to the glycine site of the NMDA receptor. Now common sense would lead one to assume that by ingesting supplemental amounts of glycine would ensure that glycine site co-activation is ensured. However the scientific literature has shown that this method has limited efficacy.
The reason that glycine administration is not very effective at stimulating NMDA activity is not completely straight forward, but one reason is because it is efficiently removed from the synapses by the reuptake regulator Glycine Transporter 1 (GT1).
Interestingly, much of the science published on the subject of stimulation of NMDA receptor activity revolves around the theory that NMDA receptor hypo-activity is a causative factor in schizophrenia. For years scientists have been investigating ways to stimulate NMDA activity as a means for treating schizophrenic patients. One of the most effective strategies has been through targeting the GT1 protein. And one of the most efficient means to do this is actually through supplementation with sarcosine.
Of course we aren’t concerned about treating schizophrenia here, what we are concerned with is maximally stimulating natural production of Test. But the mechanism in question is exactly the same for both purposes. By blocking the re-uptake of glycine you increase the concentration of glycine in neuronal synapses, and therefore increase the influence of NMDA upon nerve transmission. In essence this is the exact way some anti-depressants (such as SSRIs) work, except the goal there is to increase binding and activating of serotonin or dopamine receptors, not NMDA receptors.
Blocking glycine reuptake is not the only mechanism through which sarcosine stimulates DAA activity. Sarcosine actually can itself bind to the glycine binding site of NMDA receptors. In fact, it binds with a higher affinity than even glycine. So basically it replaces glycine as well as serves as its own reuptake inhibitor. It totally solves the glycine co-activation issue in one shot.
Knowing all these facts you can see why sarcosine produces a rather dramatic effect on NMDA neuronal transmission compared to glycine itself, or other endogenous ligands for the glycine receptor such as d-serine.
Conclusion
To summarize, for d-aspartic acid to work to its maximum potential it must be taken with an efficient stimulator of the glycine binding site on the NMDA receptor. The most efficient non-drug stimulator we know of is the natural amino acid sarcosine.
TestForce2 contains 3 grams of d-aspartic acid (as d-aspartate calcium chelate) and 3 grams of sarcosine per serving. It also is flavored with a light fruit punch flavor and slightly sweetened to provide a very pleasurable taste experience. It dissolves almost instantly.
So if you like d-aspartic acid you will love TestForce2. And if you were one of the few “non-responders” to d-aspartic acid then you will also love TestForce2 because you will no longer be a non-responder. You would be a fool to settle for any other d-aspartic acid supplement.
A recent study was published (Reproductive Biology and Endocrinology 2009, 7:120) that clearly demonstrated oral administration of d-aspartic acid increases Test in humans, lending credence to the claim of my patent application.
This study, done in Italy, showed that doses of almost 4 grams a day resulted in a rise of Test that peaked on day 12 (the last day of the study) at a level 42% greater than day zero. LH levels were also increased significantly. The study used 23 men, with all but three of them showing significant increases in Test. Furthermore, the levels of Test were still significantly increased three days after discontinuation of the d-aspartic acid. The data in the study strongly indicates that the amino acid builds up in target tissues over time, and then slowly decreases after administration is ceased.
Fortunately I found out how to solve the d-aspartic acid solubility problem. What I did was make what is known as a calcium chelate of the amino acid. What that achieved was increasing the water solubility from less than 1 gram/200 milliliters to practically limitless. See a side by side comparison. It was quite a remarkable achievement. What is also remarkable about this chelate is that it happens to be stable over a very wide pH range. Once converted to this calcium chelate the amino acid became much more user friendly, as well as more quickly absorbable, and quite possibly more bioavailable. In addition to that, you get a healthy dose of highly bioavailable calcium with each dose.
*Patent Pending
Serving Size: 7000mg (2 Scoops)
Servings Per Container: 26
Provides per serve:
D-Aspartic acid (as D-Aspartate Calcium Chelate).......3000mg
Sarcosine.....................................................................3000mg
Calcium (as D-Aspartate Calcium Chelate).....................451mg
*Percent Daily Values are based on a 2,000 calorie diet.
Let me start with some background. When d-aspartic acid (DAA) is ingested it is absorbed into the body and taken up preferentially by endocrine tissues such as the hypothalamus, pituitary, and testicles. There it stimulates the activity of what are known as NMDA receptors. NMDA receptors are located on neurons and they regulate neuronal activity. DAA binds to a specific docking site (receptor) located on the NMDA receptor known as NMDA binding site.
In the hypothalamus the stimulation of NMDA receptors leads to the production of gonadotropin releasing hormone (GnRH). GnRH then stimulates the pituitary gland to release luteinizing hormone (LH) and follicle stimulating hormone (FSH). LH and FSH then in turn travel to the testicles to initiate the process of steroidogenesis, which leads eventually to the release of test into the blood stream. Stimulation of NMDA receptors in the hypothalamus also leads to the release of growth hormone releasing hormone (GHRH) which in turn promotes the release of growth hormone from the pituitary gland.
So the key here is the NMDA receptor. The more you activate this receptor in the hypothalamus the greater the release of GnRH and GHRH, and ultimately Test and G H.
The NMDA receptor is somewhat unique in that it requires activation by two ligands (a ligand is like a “key” to a receptor). In the hypothalamus the main ligand for the NMDA receptor is d-aspartic acid. The secondary ligand (or co-activator) is the amino acid glycine. Both DAA and glycine have specific binding sites on the NMDA receptor. These sites are known as the NMDA binding site and the glycine binding site respectively. Think of it this way - just like how firing a nuclear missile requires two soldiers to turn two separate keys, so the NMDA receptor requires binding by two ligands to initiate its influence on the firing of a neuronal signal.
So to review, administration of DAA leads to it’s uptake into the hypothalamus and binding to the NMDA receptors there. And to activate the NMDA receptor you also require adequate levels of ligands that bind to the glycine site of the NMDA receptor. Now common sense would lead one to assume that by ingesting supplemental amounts of glycine would ensure that glycine site co-activation is ensured. However the scientific literature has shown that this method has limited efficacy.
The reason that glycine administration is not very effective at stimulating NMDA activity is not completely straight forward, but one reason is because it is efficiently removed from the synapses by the reuptake regulator Glycine Transporter 1 (GT1).
Interestingly, much of the science published on the subject of stimulation of NMDA receptor activity revolves around the theory that NMDA receptor hypo-activity is a causative factor in schizophrenia. For years scientists have been investigating ways to stimulate NMDA activity as a means for treating schizophrenic patients. One of the most effective strategies has been through targeting the GT1 protein. And one of the most efficient means to do this is actually through supplementation with sarcosine.
Of course we aren’t concerned about treating schizophrenia here, what we are concerned with is maximally stimulating natural production of Test. But the mechanism in question is exactly the same for both purposes. By blocking the re-uptake of glycine you increase the concentration of glycine in neuronal synapses, and therefore increase the influence of NMDA upon nerve transmission. In essence this is the exact way some anti-depressants (such as SSRIs) work, except the goal there is to increase binding and activating of serotonin or dopamine receptors, not NMDA receptors.
Blocking glycine reuptake is not the only mechanism through which sarcosine stimulates DAA activity. Sarcosine actually can itself bind to the glycine binding site of NMDA receptors. In fact, it binds with a higher affinity than even glycine. So basically it replaces glycine as well as serves as its own reuptake inhibitor. It totally solves the glycine co-activation issue in one shot.
Knowing all these facts you can see why sarcosine produces a rather dramatic effect on NMDA neuronal transmission compared to glycine itself, or other endogenous ligands for the glycine receptor such as d-serine.
Conclusion
To summarize, for d-aspartic acid to work to its maximum potential it must be taken with an efficient stimulator of the glycine binding site on the NMDA receptor. The most efficient non-drug stimulator we know of is the natural amino acid sarcosine.
TestForce2 contains 3 grams of d-aspartic acid (as d-aspartate calcium chelate) and 3 grams of sarcosine per serving. It also is flavored with a light fruit punch flavor and slightly sweetened to provide a very pleasurable taste experience. It dissolves almost instantly.
So if you like d-aspartic acid you will love TestForce2. And if you were one of the few “non-responders” to d-aspartic acid then you will also love TestForce2 because you will no longer be a non-responder. You would be a fool to settle for any other d-aspartic acid supplement.
What is D-Aspartic acid?
D-aspartic acid is the enantiomer of the dietary amino acid l-aspartic acid. Essentially this means it is the mirror image of L-aspartic acid. D-aspartic acid occurs naturally in the bodies of animals and is made by the action of the enzyme d-aspartic racemase upon dietary l-aspartic acid. D-aspartic acid is known to concentrate most specifically in neuroendocrine tissues such as the pituitary gland, pineal gland, and testes.Recent research has shown the d-aspartic acid serves as a specialized neurotransmitter in parts of the nervous system involved in hormone production. It has been shown to stimulate the release of LH and GH from the pituitary gland. Furthermore, it has also been demonstrated to have a direct stimulating effect in the testes upon Test production.A recent study was published (Reproductive Biology and Endocrinology 2009, 7:120) that clearly demonstrated oral administration of d-aspartic acid increases Test in humans, lending credence to the claim of my patent application.
This study, done in Italy, showed that doses of almost 4 grams a day resulted in a rise of Test that peaked on day 12 (the last day of the study) at a level 42% greater than day zero. LH levels were also increased significantly. The study used 23 men, with all but three of them showing significant increases in Test. Furthermore, the levels of Test were still significantly increased three days after discontinuation of the d-aspartic acid. The data in the study strongly indicates that the amino acid builds up in target tissues over time, and then slowly decreases after administration is ceased.
D-Aspartic Acid Calcium Chelate
To get the most benefit from D-aspartic acid you must use a form that is highly soluble and bioavailable. Unfortunately, straight D-aspartic acid has terrible water solubility (less than 1 gram will dissolve in 220 milliliters of water). This means that it basically sits in your digestive tract as a gritty powder and absorbs very slowly and erratically. Furthermore, at higher dosages this powder can cause digestive disturbances in susceptible individuals.Fortunately I found out how to solve the d-aspartic acid solubility problem. What I did was make what is known as a calcium chelate of the amino acid. What that achieved was increasing the water solubility from less than 1 gram/200 milliliters to practically limitless. See a side by side comparison. It was quite a remarkable achievement. What is also remarkable about this chelate is that it happens to be stable over a very wide pH range. Once converted to this calcium chelate the amino acid became much more user friendly, as well as more quickly absorbable, and quite possibly more bioavailable. In addition to that, you get a healthy dose of highly bioavailable calcium with each dose.
TESTFORCE: The Way To Go
TESTFORCE is simply d-aspartic calcium chelate powder and nothing else. It comes with a 3 gram scoop. The powder dissolves practically instantly in any beverage and it is essentially tasteless. It is recommended that people take 1-2 servings a day, and often users may find it advantageous to “load” with 2 servings (6 grams) a day for two to four weeks and then “coast” with 1 serving (3 grams) a day for the remainder of the cycle. Cycles can last anywhere from 3 weeks to indefinitely, since this product works with your body and is completely natural.*Patent Pending
Nutrition Facts
Container Size: 182 gramsServing Size: 7000mg (2 Scoops)
Servings Per Container: 26
Provides per serve:
D-Aspartic acid (as D-Aspartate Calcium Chelate).......3000mg
Sarcosine.....................................................................3000mg
Calcium (as D-Aspartate Calcium Chelate).....................451mg
*Percent Daily Values are based on a 2,000 calorie diet.
